On the role of anesthesia on the body/brain temperature differential in rats

Mingming Zhu; Deepika Nehra; Joseph J.H. Ackerman; Dmitriy A. Yablonskiy

doi:10.1016/j.jtherbio.2004.08.029

On the role of anesthesia on the body/brain temperature differential in rats

Mingming Zhu, Deepika Nehra, Joseph J.H. Ackerman, Dmitriy A. Yablonskiy

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Different anesthetics often produce distinctly different effects on blood flow, oxygen consumption and other physiological parameters in animal studies. We investigated the influence of two common anesthetics - alpha-chloralose and chloral hydrate - on the body-core/brain temperature differential in rats. The results indicate a remarkable difference of 4.34±0.64°C (mean±SD) in the body-core/brain-cortical temperature differential observed under alpha-chloralose anesthesia compared to a relatively smaller differential of 2.73±0.40°C under chloral hydrate anesthesia in rats. Temperature gradients within the brain are around 0.3°C/mm in both cases. Thus, the anesthetic utilized has the potential to markedly influence brain temperature and therefore other important physiological parameters in the brain.

Original language	English
Pages (from-to)	599-603
Number of pages	5
Journal	Journal of Thermal Biology
Volume	29
Issue number	7-8 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jtherbio.2004.08.029
State	Published - Oct 2004

Keywords

Anesthesia
Brain function
Brain metabolism
Functional MRI
Hypothermia

Access to Document

10.1016/j.jtherbio.2004.08.029

Cite this

@article{ebdff032b69b4f979da6778799729fca,

title = "On the role of anesthesia on the body/brain temperature differential in rats",

abstract = "Different anesthetics often produce distinctly different effects on blood flow, oxygen consumption and other physiological parameters in animal studies. We investigated the influence of two common anesthetics - alpha-chloralose and chloral hydrate - on the body-core/brain temperature differential in rats. The results indicate a remarkable difference of 4.34±0.64°C (mean±SD) in the body-core/brain-cortical temperature differential observed under alpha-chloralose anesthesia compared to a relatively smaller differential of 2.73±0.40°C under chloral hydrate anesthesia in rats. Temperature gradients within the brain are around 0.3°C/mm in both cases. Thus, the anesthetic utilized has the potential to markedly influence brain temperature and therefore other important physiological parameters in the brain.",

keywords = "Anesthesia, Brain function, Brain metabolism, Functional MRI, Hypothermia",

author = "Mingming Zhu and Deepika Nehra and Ackerman, {Joseph J.H.} and Yablonskiy, {Dmitriy A.}",

note = "Funding Information: The authors are grateful to Dr. Marcus E. Raichle for stimulating and helpful discussions. Contribution from Dr. James Quirk during initial stage of the project is also greatly appreciated. This study was supported by NIH Grants RO1-NS41519 and R24-CA83060 (Small Animal Imaging Resource Program).",

year = "2004",

month = oct,

doi = "10.1016/j.jtherbio.2004.08.029",

language = "English",

volume = "29",

pages = "599--603",

journal = "Journal of Thermal Biology",

issn = "0306-4565",

number = "7-8 SPEC. ISS.",

}

TY - JOUR

T1 - On the role of anesthesia on the body/brain temperature differential in rats

AU - Zhu, Mingming

AU - Nehra, Deepika

AU - Ackerman, Joseph J.H.

AU - Yablonskiy, Dmitriy A.

N1 - Funding Information: The authors are grateful to Dr. Marcus E. Raichle for stimulating and helpful discussions. Contribution from Dr. James Quirk during initial stage of the project is also greatly appreciated. This study was supported by NIH Grants RO1-NS41519 and R24-CA83060 (Small Animal Imaging Resource Program).

PY - 2004/10

Y1 - 2004/10

N2 - Different anesthetics often produce distinctly different effects on blood flow, oxygen consumption and other physiological parameters in animal studies. We investigated the influence of two common anesthetics - alpha-chloralose and chloral hydrate - on the body-core/brain temperature differential in rats. The results indicate a remarkable difference of 4.34±0.64°C (mean±SD) in the body-core/brain-cortical temperature differential observed under alpha-chloralose anesthesia compared to a relatively smaller differential of 2.73±0.40°C under chloral hydrate anesthesia in rats. Temperature gradients within the brain are around 0.3°C/mm in both cases. Thus, the anesthetic utilized has the potential to markedly influence brain temperature and therefore other important physiological parameters in the brain.

AB - Different anesthetics often produce distinctly different effects on blood flow, oxygen consumption and other physiological parameters in animal studies. We investigated the influence of two common anesthetics - alpha-chloralose and chloral hydrate - on the body-core/brain temperature differential in rats. The results indicate a remarkable difference of 4.34±0.64°C (mean±SD) in the body-core/brain-cortical temperature differential observed under alpha-chloralose anesthesia compared to a relatively smaller differential of 2.73±0.40°C under chloral hydrate anesthesia in rats. Temperature gradients within the brain are around 0.3°C/mm in both cases. Thus, the anesthetic utilized has the potential to markedly influence brain temperature and therefore other important physiological parameters in the brain.

KW - Anesthesia

KW - Brain function

KW - Brain metabolism

KW - Functional MRI

KW - Hypothermia

UR - http://www.scopus.com/inward/record.url?scp=4744374149&partnerID=8YFLogxK

U2 - 10.1016/j.jtherbio.2004.08.029

DO - 10.1016/j.jtherbio.2004.08.029

M3 - Article

AN - SCOPUS:4744374149

SN - 0306-4565

VL - 29

SP - 599

EP - 603

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

IS - 7-8 SPEC. ISS.

ER -

On the role of anesthesia on the body/brain temperature differential in rats

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this