TY - GEN
T1 - On the mechanism of extremely low frequency (ELF) electric field interactions with living tissue
AU - McLeod, K. J.
AU - Rubin, C. T.
AU - Donahue, H. J.
AU - Guilak, F.
N1 - Funding Information:
This work supported by the Orthopaedic Research and Educatiori Foundation, NIH #AR-41040, and the Electrical Power Research Institute.
Publisher Copyright:
© 1992 IEEE.
PY - 1992
Y1 - 1992
N2 - A review of the empirical observations of ELF electric field effects on living tissue has led the authors to propose that effects occur through the action of the electric polarization forces which develop at the cell surface. Such an interaction mechanism predicts that the field effects should be associated with a time-development response as well as an actual deformation of the exposed cell. These two phenomena are investigated in two distinct experimental approaches, and the results are found to be consistent with the prediction of a field:cell interaction through polarization forces. The polarization force mechanism of interaction predicts that specific morphologic (cell size, shape, and orientation) and biophysical (glycocalyx content, permeability) properties will modulate the magnitude of the electrical force on the cell and therefore dictate the cellular response to the electric field. This suggests that perhaps the particular fields can be identified in advance, simplifying the problem of determining the long-term effects of environmental field exposure.
AB - A review of the empirical observations of ELF electric field effects on living tissue has led the authors to propose that effects occur through the action of the electric polarization forces which develop at the cell surface. Such an interaction mechanism predicts that the field effects should be associated with a time-development response as well as an actual deformation of the exposed cell. These two phenomena are investigated in two distinct experimental approaches, and the results are found to be consistent with the prediction of a field:cell interaction through polarization forces. The polarization force mechanism of interaction predicts that specific morphologic (cell size, shape, and orientation) and biophysical (glycocalyx content, permeability) properties will modulate the magnitude of the electrical force on the cell and therefore dictate the cellular response to the electric field. This suggests that perhaps the particular fields can be identified in advance, simplifying the problem of determining the long-term effects of environmental field exposure.
UR - http://www.scopus.com/inward/record.url?scp=84892437386&partnerID=8YFLogxK
U2 - 10.1109/NEBC.1992.285958
DO - 10.1109/NEBC.1992.285958
M3 - Conference contribution
AN - SCOPUS:84892437386
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 65
EP - 66
BT - Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992
Y2 - 12 March 1992 through 13 March 1992
ER -