TY - JOUR
T1 - On the control of control
T2 - The role of dopamine in regulating prefrontal function and working memory
AU - Braver, Todd S.
AU - Cohen, Jonathan D.
PY - 2000
Y1 - 2000
N2 - An important aspect of cognitive control is the ability to appropriately select, update, and maintain contextual information related to behavioral goals, and to use this information to coordinate processing over extended periods. In our novel, neurobiologically based, connectionist computational model, the selection, updating, and maintenance of context occur through interactions between the prefrontal cortex (PFC) and dopamine (DA) neurotransmitter system. Phasic DA activity serves two simultaneous and synergistic functions: (1) a gating function, which regulates the access of information to active memory mechanisms subserved by PFC; and (2) a learning function, which allows the system to discover what information is relevant for selection as context. We present a simulation that establishes the computational viability of these postulated neurobiological mechanisms for subserving control functions.
AB - An important aspect of cognitive control is the ability to appropriately select, update, and maintain contextual information related to behavioral goals, and to use this information to coordinate processing over extended periods. In our novel, neurobiologically based, connectionist computational model, the selection, updating, and maintenance of context occur through interactions between the prefrontal cortex (PFC) and dopamine (DA) neurotransmitter system. Phasic DA activity serves two simultaneous and synergistic functions: (1) a gating function, which regulates the access of information to active memory mechanisms subserved by PFC; and (2) a learning function, which allows the system to discover what information is relevant for selection as context. We present a simulation that establishes the computational viability of these postulated neurobiological mechanisms for subserving control functions.
UR - http://www.scopus.com/inward/record.url?scp=52849104617&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:52849104617
SN - 1047-0387
VL - 18
SP - 712
EP - 737
JO - Attention and Performance
JF - Attention and Performance
ER -