TY - JOUR
T1 - On the Continuity between Autistic and Schizoid Personality Disorder Trait Burden
T2 - A Prospective Study in Adolescence
AU - Cook, Michal Lauren
AU - Zhang, Yi
AU - Constantino, John N.
N1 - Funding Information:
This work was supported by grants HD042541 and HD087011 (the Intellectual and Developmental Disabilities Research Center at Washington University in St. Louis) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development to Dr John Constantino. The study protocol was approved by the Washington University School of Medicine Human Research Protection Office. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Although widely conceived as distinct conditions, higher-functioning autism spectrum disorder (ASD) and schizoid personality disorder (schizoid PD) share similar clinical symptomatology. This study explored the relationship between the two disorders by collecting extensively validated measures of autistic trait burden (Social Responsive Scale, Second Edition) and schizoid PD affectation (Diagnostic Interview for Genetic Studies) from clinically ascertained verbal males with and without autism ages 12 to 25 years (N = 72) via parent, teacher, and self-report. Although only a small minority of adolescents with ASD met full diagnostic criteria for schizoid PD, participants with ASD endorsed a continuous distribution of schizoid PD traits that reflected a pronounced pathological shift in comparison with those in the control group, with one half of ASD males experiencing three or more Diagnostic and Statistical Manual of Mental Disorders, 4th Edition schizoid PD criterion items "often" or "almost always." Results suggest significant amplification of schizoid PD trait burden in adolescents with ASD. ASD-specific interventions should be considered for patients with schizoid PD with premorbid histories of ASD.
AB - Although widely conceived as distinct conditions, higher-functioning autism spectrum disorder (ASD) and schizoid personality disorder (schizoid PD) share similar clinical symptomatology. This study explored the relationship between the two disorders by collecting extensively validated measures of autistic trait burden (Social Responsive Scale, Second Edition) and schizoid PD affectation (Diagnostic Interview for Genetic Studies) from clinically ascertained verbal males with and without autism ages 12 to 25 years (N = 72) via parent, teacher, and self-report. Although only a small minority of adolescents with ASD met full diagnostic criteria for schizoid PD, participants with ASD endorsed a continuous distribution of schizoid PD traits that reflected a pronounced pathological shift in comparison with those in the control group, with one half of ASD males experiencing three or more Diagnostic and Statistical Manual of Mental Disorders, 4th Edition schizoid PD criterion items "often" or "almost always." Results suggest significant amplification of schizoid PD trait burden in adolescents with ASD. ASD-specific interventions should be considered for patients with schizoid PD with premorbid histories of ASD.
KW - Autism spectrum disorder
KW - adolescence
KW - differential diagnosisdiagnosis
KW - schizoid personality disorder
KW - social impairment
UR - http://www.scopus.com/inward/record.url?scp=85078558627&partnerID=8YFLogxK
U2 - 10.1097/NMD.0000000000001105
DO - 10.1097/NMD.0000000000001105
M3 - Article
C2 - 31856140
AN - SCOPUS:85078558627
SN - 0022-3018
VL - 208
SP - 94
EP - 100
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 2
ER -