TY - JOUR
T1 - On navigating the human cerebral cortex
T2 - Response to 'in praise of tedious anatomy'
AU - Van Essen, David C.
AU - Dierker, Donna
N1 - Funding Information:
We thank Erin Reid and Susan Danker for technical support, Antonia Hamilton for providing the Functional Imaging Net database datasets. Supported by NIH Grant R01-MH-60974, funded by the National Institute of Mental Health, the National Institute for Biomedical Imaging and Bioengineering, and the National Science Foundation.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Individual variability of the human cerebral cortex is a source of both fascination and frustration. The fascination arises because variability in cortical structure and function may account for many aspects of our unique personalities and cognitive capabilities. For neuroimagers, the frustration arises because variability presents serious obstacles when attempting to assign particular functional activation patterns to specific cortical areas. Devlin and Poldrack cogently summarize many of the key issues, and they make useful suggestions for linking function to anatomy using a standardized stereotaxic space. This commentary provides a broader perspective on the nature of individual variability that has implications for the choice of strategies used to compensate for variability. It also includes information about the actual differences between various registration strategies and introduces a new strategy for converting neuroimaging data to a standard stereotaxic space.
AB - Individual variability of the human cerebral cortex is a source of both fascination and frustration. The fascination arises because variability in cortical structure and function may account for many aspects of our unique personalities and cognitive capabilities. For neuroimagers, the frustration arises because variability presents serious obstacles when attempting to assign particular functional activation patterns to specific cortical areas. Devlin and Poldrack cogently summarize many of the key issues, and they make useful suggestions for linking function to anatomy using a standardized stereotaxic space. This commentary provides a broader perspective on the nature of individual variability that has implications for the choice of strategies used to compensate for variability. It also includes information about the actual differences between various registration strategies and introduces a new strategy for converting neuroimaging data to a standard stereotaxic space.
UR - http://www.scopus.com/inward/record.url?scp=34548533672&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2007.02.021
DO - 10.1016/j.neuroimage.2007.02.021
M3 - Comment/debate
C2 - 17766148
AN - SCOPUS:34548533672
SN - 1053-8119
VL - 37
SP - 1050
EP - 1054
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -