Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Sonia Olivia Spitzer, Sergey Sitnikov, Yasmine Kamen, Kimberley Anne Evans, Deborah Kronenberg-Versteeg, Sabine Dietmann, Omar de Faria, Sylvia Agathou, Ragnhildur Thóra Káradóttir

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43 Scopus citations

Abstract

Spitzer et al. show that oligodendrocyte progenitor cells (OPCs) acquire ion channels and sensitivity to neuronal activity that differ between region and age. The onset and decline of ion channels follow developmental milestones. This heterogeneity indicates different functional states of OPCs.

Original languageEnglish
Pages (from-to)459-471.e5
JournalNeuron
Volume101
Issue number3
DOIs
StatePublished - Feb 6 2019
Externally publishedYes

Keywords

  • bioelectricity
  • differentiation
  • electrophysiology
  • glia
  • glutamate
  • ion channels
  • myelin
  • neurotransmitter receptors
  • oligodendrocyte
  • oligodendrocyte precursor cell

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  • Cite this

    Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T. (2019). Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age. Neuron, 101(3), 459-471.e5. https://doi.org/10.1016/j.neuron.2018.12.020