Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Sonia Olivia Spitzer; Sergey Sitnikov; Yasmine Kamen; Kimberley Anne Evans; Deborah Kronenberg-Versteeg; Sabine Dietmann; Omar de Faria; Sylvia Agathou; Ragnhildur Thóra Káradóttir

doi:10.1016/j.neuron.2018.12.020

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Sonia Olivia Spitzer, Sergey Sitnikov, Yasmine Kamen, Kimberley Anne Evans, Deborah Kronenberg-Versteeg, Sabine Dietmann, Omar de Faria, Sylvia Agathou, Ragnhildur Thóra Káradóttir

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

Spitzer et al. show that oligodendrocyte progenitor cells (OPCs) acquire ion channels and sensitivity to neuronal activity that differ between region and age. The onset and decline of ion channels follow developmental milestones. This heterogeneity indicates different functional states of OPCs.

Original language	English
Pages (from-to)	459-471.e5
Journal	Neuron
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2018.12.020
State	Published - Feb 6 2019

Keywords

bioelectricity
differentiation
electrophysiology
glia
glutamate
ion channels
myelin
neurotransmitter receptors
oligodendrocyte
oligodendrocyte precursor cell

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10.1016/j.neuron.2018.12.020

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title = "Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age",

abstract = "Spitzer et al. show that oligodendrocyte progenitor cells (OPCs) acquire ion channels and sensitivity to neuronal activity that differ between region and age. The onset and decline of ion channels follow developmental milestones. This heterogeneity indicates different functional states of OPCs.",

keywords = "bioelectricity, differentiation, electrophysiology, glia, glutamate, ion channels, myelin, neurotransmitter receptors, oligodendrocyte, oligodendrocyte precursor cell",

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AU - Sitnikov, Sergey

AU - Kamen, Yasmine

AU - Evans, Kimberley Anne

AU - Kronenberg-Versteeg, Deborah

AU - Dietmann, Sabine

AU - de Faria, Omar

AU - Agathou, Sylvia

AU - Káradóttir, Ragnhildur Thóra

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KW - differentiation

KW - electrophysiology

KW - glia

KW - glutamate

KW - ion channels

KW - myelin

KW - neurotransmitter receptors

KW - oligodendrocyte

KW - oligodendrocyte precursor cell

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Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

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