Older age at diagnosis of Hirschsprung disease decreases risk of postoperative enterocolitis, but resection of additional ganglionated bowel does not

Ramanath N. Haricharan, Jeong Meen Seo, David R. Kelly, Elizabeth C. Mroczek-Musulman, Charles J. Aprahamian, Traci L. Morgan, Keith E. Georgeson, Carroll M. Harmon, Jacqueline M. Saito, Douglas C. Barnhart

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57 Scopus citations

Abstract

Purpose: This study was conducted to determine the effect of age at diagnosis and length of ganglionated bowel resected on postoperative Hirschsprung-associated enterocolitis (HAEC). Methods: Children who underwent endorectal pull-through (ERPT) between January 1993 and December 2004 were retrospectively reviewed. t Test, analysis of variance, Kaplan-Meier, and Cox's proportional hazards analyses were performed. Results: Fifty-two children with Hirschsprung disease (median age, 25 days; range, 2 days-16 years) were included. Nineteen (37%) had admissions for HAEC. Proportional hazards regression showed that HAEC admissions decreased by 30% with each doubling of age at diagnosis (P = .03) and increased 9-fold when postoperative stricture was present (P < .01), after controlling for type of ERPT, trisomy 21, transition zone level, and preoperative enterocolitis. Thirty-six children, with age at initial operation less than 6 months, were grouped based on length of ganglionated bowel excised (A [5 cm] and B [>5 cm]). No significant difference in the number of HAEC admissions during initial 2 years post-ERPT was seen between groups A (n = 18) and B (n = 18). The study had a power of 0.8 to detect a difference of 1 admission over 2 years. Conclusions: Children diagnosed with Hirschsprung disease at younger ages are at a greater risk for postoperative enterocolitis. Excising a longer margin of ganglionated bowel (>5 cm) does not seem to be beneficial in decreasing HAEC admissions.

Original languageEnglish
Pages (from-to)1115-1123
Number of pages9
JournalJournal of Pediatric Surgery
Volume43
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Children
  • Endorectal pull-through
  • Enterocolitis
  • Ganglionated bowel
  • Hirschsprung disease
  • Postoperative complications
  • Risk factors

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