Old T Cells Interfer(on) with Neurogenesis

Justin Rustenhoven; Jasmin Herz; Jonathan Kipnis

doi:10.1016/j.it.2019.07.007

Old T Cells Interfer(on) with Neurogenesis

Justin Rustenhoven
, Jasmin Herz
, Jonathan Kipnis

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.

Original language	English
Pages (from-to)	783-785
Number of pages	3
Journal	Trends in Immunology
Volume	40
Issue number	9
DOIs	https://doi.org/10.1016/j.it.2019.07.007
State	Published - Sep 2019

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title = "Old T Cells Interfer(on) with Neurogenesis",

abstract = "Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.",

author = "Justin Rustenhoven and Jasmin Herz and Jonathan Kipnis",

note = "Funding Information: Figure was created with BioRender.com. J.K. is an Advisor to PureTech Health/Ariya. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

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doi = "10.1016/j.it.2019.07.007",

language = "English",

volume = "40",

pages = "783--785",

journal = "Trends in Immunology",

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T1 - Old T Cells Interfer(on) with Neurogenesis

AU - Rustenhoven, Justin

AU - Herz, Jasmin

AU - Kipnis, Jonathan

PY - 2019/9

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N2 - Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.

AB - Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.

UR - https://www.scopus.com/pages/publications/85070541560

U2 - 10.1016/j.it.2019.07.007

DO - 10.1016/j.it.2019.07.007

M3 - Short survey

C2 - 31422900

AN - SCOPUS:85070541560

SN - 1471-4906

VL - 40

SP - 783

EP - 785

JO - Trends in Immunology

JF - Trends in Immunology

IS - 9

ER -

Old T Cells Interfer(on) with Neurogenesis

Abstract

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