Old T Cells Interfer(on) with Neurogenesis

Justin Rustenhoven, Jasmin Herz, Jonathan Kipnis

Research output: Contribution to journalShort surveypeer-review

Abstract

Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.

Original languageEnglish
Pages (from-to)783-785
Number of pages3
JournalTrends in Immunology
Volume40
Issue number9
DOIs
StatePublished - Sep 2019

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