TY - JOUR
T1 - Old T Cells Interfer(on) with Neurogenesis
AU - Rustenhoven, Justin
AU - Herz, Jasmin
AU - Kipnis, Jonathan
N1 - Funding Information:
Figure was created with BioRender.com. J.K. is an Advisor to PureTech Health/Ariya.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/9
Y1 - 2019/9
N2 - Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.
AB - Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al., Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=85070541560&partnerID=8YFLogxK
U2 - 10.1016/j.it.2019.07.007
DO - 10.1016/j.it.2019.07.007
M3 - Short survey
C2 - 31422900
AN - SCOPUS:85070541560
SN - 1471-4906
VL - 40
SP - 783
EP - 785
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -