Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxity

Nuri B. Farber, John Foster, Nadine L. Duhan, John W. Olney

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Antagonists of the N-methyl-D-Aspartate (NMDA) subtype of glutamate receptor (e.g., phencyclidine, ketamine, MK-801) cause a schizophrenia-like psychosis in humans and neurotoxicity in the adult rat brain. We report here that clozapine and structurally related agents (olanzapine, fluperlapine, loxapine, amoxapine) can prevent NMDA antagonist neurotoxicity in the rat with a rank order corresponding to their ability to mimic the antipsychotic properties of clozapine.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalSchizophrenia research
Volume21
Issue number1
DOIs
StatePublished - Jul 31 1996

Keywords

  • Clozapine
  • MK- 801
  • NMDA antagonists
  • Neurotoxicity
  • Novel antipsychotics
  • Olanzapine
  • Phencyclidine
  • Schizophrenia

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