Oculodentodigital dysplasia (ODDD) syndrome is an uncommon inherited disorder with eye and facial abnormalities, syndactyly, and defects in tooth enamel. Some of the previously reported patients with ODDD syndrome also manifested spastic quadriparesis. We describe a patient with sporadic ODDD syndrome referred for evaluation of progressive spastic paraparesis. Magnetic resonance imaging of the brain demonstrated abnormal white matter, which suggests an explanation for the observed spastic paraparesis.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalAmerican journal of medical genetics
Issue number1
StatePublished - 1991


  • hereditary spastic paraparesis
  • leukodystrophy


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