Ocular manifestations of systemic lupus erythematosus

John B. Davies, Prabakar Kumar Rao

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Purpose of review: To describe the ophthalmic manifestations of systemic lupus erythematosus and to review recent advances in our understanding of the pathogenesis and treatment of this condition. Recent findings Significant vision loss and associated ocular morbidity are possible in systemic lupus erythematosus, particularly in cases of retinal or central nervous system involvement. Considerable progress has been made in our understanding of the immunologic mechanisms of disease. Approaches to treatment include the use of systemic immunosuppressive medications. Biologic agents are being developed to target specific aspects of the immune response. Summary Ocular involvement is not uncommon in systemic lupus erythematosus. Aggressive systemic therapy is often needed to control the disease. Several new immunomodulatory treatment strategies are being developed which may show great promise in the future.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalCurrent Opinion in Ophthalmology
Issue number6
StatePublished - Nov 2008


  • Antiphospholipid antibody
  • Dry eye
  • Immunosuppressive therapy
  • Retinopathy
  • Systemic lupus erythematosus


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