Ocular manifestations of systemic amyloidosis

Margaret M. Reynolds, Kevin K. Veverka, Morie A. Gertz, Angela Dispenzieri, Steven R. Zeldenrust, Nelson Leung, Jose S. Pulido

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Purpose: To describe ophthalmic manifestations of systemic amyloidosis, a group of devastating conditions. Methods: A retrospective chart review including patients who had ocular examinations at Mayo Clinic between January 1, 1985, and April 1, 2014, and a diagnosis of light-chain (AL), secondary (AA), or nontransthyretin familial amyloidosis was undertaken. Sixty-eight patients with AL amyloidosis, eight patients with AA amyloidosis, and five patients with nontransthyretin familial amyloidosis were included. Results: Of 68 patients, 8 patients (14 eyes) with AL amyloidosis had ocular involvement secondary to conjunctiva, temporal artery, extraocular muscle, trabecular meshwork, and cranial nerve deposition. One of the five patients with nontransthyretin familial amyloidosis had gelsolin-related corneal dystrophy. No patients with AA amyloidosis (n = 8) had ophthalmic manifestations. Conclusion: Systemic amyloidosis can lead to ocular morbidity. Patients with AL amyloidosis had involvement of the temporal artery, conjunctiva, extraocular muscles, trabecular meshwork, and cranial nerves. Those with gelsolin nontransthyretin familial amyloidosis were susceptible to corneal dystrophy. Patients with AA amyloidosis did not manifest ophthalmic involvement. Finally, if ocular amyloidosis is detected, patients should be referred for systemic workup.

Original languageEnglish
Pages (from-to)1371-1376
Number of pages6
Issue number7
StatePublished - Jul 1 2018


  • ApoA1
  • ApoA2
  • Beta-2 microglobulin
  • Gelsolin
  • Light-chain (AL) amyloidosis
  • Lysozyme
  • Nontransthyretin familial amyloidosis
  • Secondary (AA) amyloidosis
  • Serum amyloid A (SAA)
  • Systemic amyloidosis


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