@article{89c5924749ba49769d175cd1cf3ab69a,
title = "Obstructive sleep apnea treatment, slow wave activity, and amyloid-β",
abstract = "Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid-β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. In this study, SWA and CSF Aβ were measured in participants with OSA before and 1 to 4 months after treatment. OSA treatment increased SWA, and SWA was significantly correlated with lower Aβ after treatment. Greater improvement in OSA was associated with greater decreases in Aβ. We propose a model whereby OSA treatment may affect both Aβ release and clearance. Ann Neurol 2018 ANN NEUROL 2019;85:291–295.",
author = "Ju, {Yo El S.} and Zangrilli, {Margaret A.} and Finn, {Mary Beth} and Fagan, {Anne M.} and Holtzman, {David M.}",
note = "Funding Information: Research reported in this article was supported by an investigator-initiated grant from Philips Respironics (no number), NIH awards (K23NS089922, UL1RR024992 subaward KL2TR000450), and a Washington University Institute of Clinical and Translational Sciences grant (UL1TR000448) from the NIH National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH. Publisher Copyright: {\textcopyright} 2018 American Neurological Association",
year = "2019",
month = feb,
doi = "10.1002/ana.25408",
language = "English",
volume = "85",
pages = "291--295",
journal = "Annals of Neurology",
issn = "0364-5134",
number = "2",
}