@article{4efc20ad52b94d2eb155152cc32ab8d1,
title = "Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid",
abstract = "We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154–159.",
author = "Ju, {Yo El S.} and Finn, {Mary Beth} and Sutphen, {Courtney L.} and Herries, {Elizabeth M.} and Jerome, {Gina M.} and Ladenson, {Jack H.} and Crimmins, {Daniel L.} and Fagan, {Anne M.} and Holtzman, {David M.}",
note = "Funding Information: Research reported in this publication was supported by National Institutes of Health awards K23-NS089922, UL1RR024992, Sub-Award KL2 TR000450, P01-AG026276 (to J.C.M., principal investigator [PI]), P01-NS074969, and P01-AG03991 (to J.C.M., PI); the J.P.B Foundation; and the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2016 American Neurological Association",
year = "2016",
month = jul,
day = "1",
doi = "10.1002/ana.24672",
language = "English",
volume = "80",
pages = "154--159",
journal = "Annals of Neurology",
issn = "0364-5134",
number = "1",
}