Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

Yo El S. Ju; Mary Beth Finn; Courtney L. Sutphen; Elizabeth M. Herries; Gina M. Jerome; Jack H. Ladenson; Daniel L. Crimmins; Anne M. Fagan; David M. Holtzman

doi:10.1002/ana.24672

Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

Yo El S. Ju, Mary Beth Finn, Courtney L. Sutphen, Elizabeth M. Herries, Gina M. Jerome, Jack H. Ladenson, Daniel L. Crimmins, Anne M. Fagan, David M. Holtzman

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154–159.

Original language	English
Pages (from-to)	154-159
Number of pages	6
Journal	Annals of neurology
Volume	80
Issue number	1
DOIs	https://doi.org/10.1002/ana.24672
State	Published - Jul 1 2016

Access to Document

10.1002/ana.24672

Cite this

@article{4efc20ad52b94d2eb155152cc32ab8d1,

title = "Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid",

abstract = "We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154–159.",

author = "Ju, {Yo El S.} and Finn, {Mary Beth} and Sutphen, {Courtney L.} and Herries, {Elizabeth M.} and Jerome, {Gina M.} and Ladenson, {Jack H.} and Crimmins, {Daniel L.} and Fagan, {Anne M.} and Holtzman, {David M.}",

note = "Publisher Copyright: {\textcopyright} 2016 American Neurological Association",

year = "2016",

month = jul,

day = "1",

doi = "10.1002/ana.24672",

language = "English",

volume = "80",

pages = "154--159",

journal = "Annals of neurology",

issn = "0364-5134",

number = "1",

}

TY - JOUR

T1 - Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

AU - Ju, Yo El S.

AU - Finn, Mary Beth

AU - Sutphen, Courtney L.

AU - Herries, Elizabeth M.

AU - Jerome, Gina M.

AU - Ladenson, Jack H.

AU - Crimmins, Daniel L.

AU - Fagan, Anne M.

AU - Holtzman, David M.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154–159.

AB - We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154–159.

UR - http://www.scopus.com/inward/record.url?scp=84977646690&partnerID=8YFLogxK

U2 - 10.1002/ana.24672

DO - 10.1002/ana.24672

M3 - Article

C2 - 27129429

AN - SCOPUS:84977646690

SN - 0364-5134

VL - 80

SP - 154

EP - 159

JO - Annals of neurology

JF - Annals of neurology

IS - 1

ER -

Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

Abstract

Access to Document

Other files and links

Fingerprint

Cite this