Observations on the biochemical effects of transfusion of citrate-phosphate-dextrose stored blood in man techniques in incus transposition and replacement

Robert N. Miller; Robert Engelhardt; John A. Collins; Eduardo Slatopolsky; Jack H. Ladenson

doi:10.1288/00005537-197608000-00019

Observations on the biochemical effects of transfusion of citrate-phosphate-dextrose stored blood in man techniques in incus transposition and replacement

Robert N. Miller, Robert Engelhardt, John A. Collins, Eduardo Slatopolsky, Jack H. Ladenson

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Abstract

Preliminary data on the biochemical effects of the transfusion of three units of CPD blood in man is presented. Free (ionized) calcium was found to decrease approximately two minutes following initiation of the transfusion of CPD stored blood at a rate of 50 ml/min. Due to mixing problems, arterial and not venous specimens were found necessary to monitor accurately the severity of these decreases. Parathyroid hormone in the peripheral blood was found to increase two to four minutes after the initiation of transfusion. Decreases in blood pressure were observed during transfusion. The blood pressure recovered when the transfusion was stopped and did not decrease any further after restarting the transfusion, even when comparable free calcium levels were achieved. Insulin levels were found not to increase or decrease consistently, and only modest changes in plasma potassium were observed.

Original language	English
Pages (from-to)	1272-1279
Number of pages	8
Journal	Laryngoscope
Volume	86
Issue number	8
DOIs	https://doi.org/10.1288/00005537-197608000-00019
State	Published - Aug 1976

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title = "Observations on the biochemical effects of transfusion of citrate-phosphate-dextrose stored blood in man techniques in incus transposition and replacement",

abstract = "Preliminary data on the biochemical effects of the transfusion of three units of CPD blood in man is presented. Free (ionized) calcium was found to decrease approximately two minutes following initiation of the transfusion of CPD stored blood at a rate of 50 ml/min. Due to mixing problems, arterial and not venous specimens were found necessary to monitor accurately the severity of these decreases. Parathyroid hormone in the peripheral blood was found to increase two to four minutes after the initiation of transfusion. Decreases in blood pressure were observed during transfusion. The blood pressure recovered when the transfusion was stopped and did not decrease any further after restarting the transfusion, even when comparable free calcium levels were achieved. Insulin levels were found not to increase or decrease consistently, and only modest changes in plasma potassium were observed.",

author = "Miller, {Robert N.} and Robert Engelhardt and Collins, {John A.} and Eduardo Slatopolsky and Ladenson, {Jack H.}",

year = "1976",

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journal = "Laryngoscope",

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T1 - Observations on the biochemical effects of transfusion of citrate-phosphate-dextrose stored blood in man techniques in incus transposition and replacement

AU - Miller, Robert N.

AU - Engelhardt, Robert

AU - Collins, John A.

AU - Slatopolsky, Eduardo

AU - Ladenson, Jack H.

PY - 1976/8

Y1 - 1976/8

N2 - Preliminary data on the biochemical effects of the transfusion of three units of CPD blood in man is presented. Free (ionized) calcium was found to decrease approximately two minutes following initiation of the transfusion of CPD stored blood at a rate of 50 ml/min. Due to mixing problems, arterial and not venous specimens were found necessary to monitor accurately the severity of these decreases. Parathyroid hormone in the peripheral blood was found to increase two to four minutes after the initiation of transfusion. Decreases in blood pressure were observed during transfusion. The blood pressure recovered when the transfusion was stopped and did not decrease any further after restarting the transfusion, even when comparable free calcium levels were achieved. Insulin levels were found not to increase or decrease consistently, and only modest changes in plasma potassium were observed.

AB - Preliminary data on the biochemical effects of the transfusion of three units of CPD blood in man is presented. Free (ionized) calcium was found to decrease approximately two minutes following initiation of the transfusion of CPD stored blood at a rate of 50 ml/min. Due to mixing problems, arterial and not venous specimens were found necessary to monitor accurately the severity of these decreases. Parathyroid hormone in the peripheral blood was found to increase two to four minutes after the initiation of transfusion. Decreases in blood pressure were observed during transfusion. The blood pressure recovered when the transfusion was stopped and did not decrease any further after restarting the transfusion, even when comparable free calcium levels were achieved. Insulin levels were found not to increase or decrease consistently, and only modest changes in plasma potassium were observed.

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JO - Laryngoscope

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ER -

Observations on the biochemical effects of transfusion of citrate-phosphate-dextrose stored blood in man techniques in incus transposition and replacement

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