Obesity and risk of coronary heart disease in women

John C. Stevenson; Ian F. Godsland; Raymond Bruce; Victor Wynn; Patrick J. Bradley; Geoffrey Modest; Maurice Goretsky; Joann E. Manson; Graham A. Colditz; Meir J. Stampfer; Walter C. Willett; Bernard Rosner; Richard R. Monson; Frank E. Speizer; Charles H. Hennekens

doi:10.1056/NEJM199010183231614

Obesity and risk of coronary heart disease in women

John C. Stevenson
, Ian F. Godsland
, Raymond Bruce
, Victor Wynn
, Patrick J. Bradley
, Geoffrey Modest
, Maurice Goretsky
, Joann E. Manson
, Graham A. Colditz
, Meir J. Stampfer
, Walter C. Willett
, Bernard Rosner
, Richard R. Monson
, Frank E. Speizer
, Charles H. Hennekens

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)¹ describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,² ³ ⁴ which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.

Original language	English
Pages (from-to)	1143-1146
Number of pages	4
Journal	New England Journal of Medicine
Volume	323
Issue number	16
DOIs	https://doi.org/10.1056/NEJM199010183231614
State	Published - Oct 18 1990

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Stevenson, J. C., Godsland, I. F., Bruce, R., Wynn, V., Bradley, P. J., Modest, G., Goretsky, M., Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., Rosner, B., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990). Obesity and risk of coronary heart disease in women. New England Journal of Medicine, 323(16), 1143-1146. https://doi.org/10.1056/NEJM199010183231614

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title = "Obesity and risk of coronary heart disease in women",

abstract = "To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)1 describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,2 3 4 which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.",

author = "Stevenson, \{John C.\} and Godsland, \{Ian F.\} and Raymond Bruce and Victor Wynn and Bradley, \{Patrick J.\} and Geoffrey Modest and Maurice Goretsky and Manson, \{Joann E.\} and Colditz, \{Graham A.\} and Stampfer, \{Meir J.\} and Willett, \{Walter C.\} and Bernard Rosner and Monson, \{Richard R.\} and Speizer, \{Frank E.\} and Hennekens, \{Charles H.\}",

year = "1990",

month = oct,

day = "18",

doi = "10.1056/NEJM199010183231614",

language = "English",

volume = "323",

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TY - JOUR

T1 - Obesity and risk of coronary heart disease in women

AU - Stevenson, John C.

AU - Godsland, Ian F.

AU - Bruce, Raymond

AU - Wynn, Victor

AU - Bradley, Patrick J.

AU - Modest, Geoffrey

AU - Goretsky, Maurice

AU - Manson, Joann E.

AU - Colditz, Graham A.

AU - Stampfer, Meir J.

AU - Willett, Walter C.

AU - Rosner, Bernard

AU - Monson, Richard R.

AU - Speizer, Frank E.

AU - Hennekens, Charles H.

PY - 1990/10/18

Y1 - 1990/10/18

N2 - To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)1 describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,2 3 4 which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.

AB - To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)1 describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,2 3 4 which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.

UR - https://www.scopus.com/pages/publications/0025107270

U2 - 10.1056/NEJM199010183231614

DO - 10.1056/NEJM199010183231614

M3 - Letter

C2 - 2215587

AN - SCOPUS:0025107270

SN - 0028-4793

VL - 323

SP - 1143

EP - 1146

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 16

ER -

Obesity and risk of coronary heart disease in women

Abstract

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