TY - JOUR
T1 - Obesity and risk of coronary heart disease in women
AU - Stevenson, John C.
AU - Godsland, Ian F.
AU - Bruce, Raymond
AU - Wynn, Victor
AU - Bradley, Patrick J.
AU - Modest, Geoffrey
AU - Goretsky, Maurice
AU - Manson, Joann E.
AU - Colditz, Graham A.
AU - Stampfer, Meir J.
AU - Willett, Walter C.
AU - Rosner, Bernard
AU - Monson, Richard R.
AU - Speizer, Frank E.
AU - Hennekens, Charles H.
PY - 1990/10/18
Y1 - 1990/10/18
N2 - To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)1 describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,2 3 4 which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.
AB - To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)1 describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most important aspect of adiposity in relation to the risk of coronary heart disease and mortality — namely, body-fat distribution,2 3 4 which was not measured in this study. The authors briefly acknowledge this defect. Central (android) obesity, but not lower-body-segment (gynecoid) obesity, is strongly linked with the risk factors for coronary heart disease, specifically elevated LDL cholesterol levels, reduced HDL cholesterol levels, elevated.
UR - http://www.scopus.com/inward/record.url?scp=0025107270&partnerID=8YFLogxK
U2 - 10.1056/NEJM199010183231614
DO - 10.1056/NEJM199010183231614
M3 - Letter
C2 - 2215587
AN - SCOPUS:0025107270
SN - 0028-4793
VL - 323
SP - 1143
EP - 1146
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -