TY - JOUR
T1 - Obesity alters gut microbial ecology
AU - Ley, Ruth E.
AU - Bäckhed, Fredrik
AU - Turnbaugh, Peter
AU - Lozupone, Catherine A.
AU - Knight, Robin D.
AU - Gordon, Jeffrey I.
PY - 2005/8/2
Y1 - 2005/8/2
N2 - We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
AB - We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
KW - Energy balance/obesity
KW - Host-microbial interactions
KW - Intestinal bacterial diversity
KW - Phylogenetics
KW - ob/ob mice
UR - http://www.scopus.com/inward/record.url?scp=23344442120&partnerID=8YFLogxK
U2 - 10.1073/pnas.0504978102
DO - 10.1073/pnas.0504978102
M3 - Article
C2 - 16033867
AN - SCOPUS:23344442120
SN - 0027-8424
VL - 102
SP - 11070
EP - 11075
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 31
ER -