O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes

Martin D. Witte, Bogdan I. Florea, Martijn Verdoes, Oloruntosin Adeyanju, Gijs A. Van Der Marel, Herman S. Overkleeft

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

(Chemical Equation Presented) Cytosolic and nuclear proteins may be subject to both O-GlcNAcylation and proteasomal degradation. By means of activity-based profiling, we demonstrate that O-GlcNAc serinecontaining peptide epoxyketones bind to the proteasome catalytic active sites and thus provide the first clear evidence that proteasomes recognize peptides post-translationally modified with a GlcNAc moiety.

Original languageEnglish
Pages (from-to)12064-12065
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number34
DOIs
StatePublished - Sep 2 2009

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