O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

Shannon Weiman; Satoshi Uchiyama; Feng Ying C. Lin; Donald Chaffin; Ajit Varki; Victor Nizet; Amanda L. Lewis

doi:10.1042/BJ20100232

O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

Shannon Weiman
, Satoshi Uchiyama
, Feng Ying C. Lin
, Donald Chaffin
, Ajit Varki
, Victor Nizet
, Amanda L. Lewis

Department of Molecular Microbiology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Biochemical Journal
Volume	428
Issue number	2
DOIs	https://doi.org/10.1042/BJ20100232
State	Published - Jun 1 2010

Keywords

Capsular polysaccharide
Neutrophil
O-acetylation
Sialic acid
Streptococcus agalactiae

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10.1042/BJ20100232

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title = "O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence",

abstract = "GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.",

keywords = "Capsular polysaccharide, Neutrophil, O-acetylation, Sialic acid, Streptococcus agalactiae",

author = "Shannon Weiman and Satoshi Uchiyama and Lin, \{Feng Ying C.\} and Donald Chaffin and Ajit Varki and Victor Nizet and Lewis, \{Amanda L.\}",

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doi = "10.1042/BJ20100232",

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T1 - O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

AU - Weiman, Shannon

AU - Uchiyama, Satoshi

AU - Lin, Feng Ying C.

AU - Chaffin, Donald

AU - Varki, Ajit

AU - Nizet, Victor

AU - Lewis, Amanda L.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

AB - GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

KW - Capsular polysaccharide

KW - Neutrophil

KW - O-acetylation

KW - Sialic acid

KW - Streptococcus agalactiae

UR - https://www.scopus.com/pages/publications/77952575801

U2 - 10.1042/BJ20100232

DO - 10.1042/BJ20100232

M3 - Article

C2 - 20334627

AN - SCOPUS:77952575801

SN - 0264-6021

VL - 428

SP - 163

EP - 168

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

Abstract

Keywords

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