O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

Shannon Weiman; Satoshi Uchiyama; Feng Ying C. Lin; Donald Chaffin; Ajit Varki; Victor Nizet; Amanda L. Lewis

doi:10.1042/BJ20100232

O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

Shannon Weiman, Satoshi Uchiyama, Feng Ying C. Lin, Donald Chaffin, Ajit Varki, Victor Nizet, Amanda L. Lewis

Department of Molecular Microbiology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Biochemical Journal
Volume	428
Issue number	2
DOIs	https://doi.org/10.1042/BJ20100232
State	Published - Jun 1 2010

Keywords

Capsular polysaccharide
Neutrophil
O-acetylation
Sialic acid
Streptococcus agalactiae

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10.1042/BJ20100232

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title = "O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence",

abstract = "GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.",

keywords = "Capsular polysaccharide, Neutrophil, O-acetylation, Sialic acid, Streptococcus agalactiae",

author = "Shannon Weiman and Satoshi Uchiyama and Lin, {Feng Ying C.} and Donald Chaffin and Ajit Varki and Victor Nizet and Lewis, {Amanda L.}",

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AU - Weiman, Shannon

AU - Uchiyama, Satoshi

AU - Lin, Feng Ying C.

AU - Chaffin, Donald

AU - Varki, Ajit

AU - Nizet, Victor

AU - Lewis, Amanda L.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

AB - GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

KW - Capsular polysaccharide

KW - Neutrophil

KW - O-acetylation

KW - Sialic acid

KW - Streptococcus agalactiae

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SP - 163

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JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

O-acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

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Keywords

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