Numbing the Senses: Role of TRPA1 in Mechanical and Cold Sensation

Gina M. Story; Robert W. Gereau IV

doi:10.1016/j.neuron.2006.04.009

Numbing the Senses: Role of TRPA1 in Mechanical and Cold Sensation

Gina M. Story, Robert W. Gereau IV

Research output: Contribution to journal › Short survey › peer-review

31 Scopus citations

Abstract

In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Neuron
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2006.04.009
State	Published - Apr 20 2006

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abstract = "In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.",

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AB - In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.

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