Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial

Paulette D. Chandler, Edward L. Giovannucci, Jamil B. Scott, Gary G. Bennett, Kimmie Ng, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, Bettina F. Drake

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Results: With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA,-0.0004 ng/mL (P = 0.94) and total PSA,-0.004 ng/mL (P = 0.92) for each additional 1, 000 U/d of vitamin D3. Conclusion: Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA.

Background: Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men.

Methods: During three winters from 2007 to 2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a four-arm, double-blind trial for 3 months of placebo, 1, 000, 2, 000, or 4, 000Uof vitamin D3. At baseline and 3 months, free and total PSA was measured.

Impact: These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.

Original languageEnglish
Pages (from-to)1944-1947
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Issue number9
StatePublished - Sep 1 2014


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