TY - JOUR
T1 - Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial
AU - Chandler, Paulette D.
AU - Giovannucci, Edward L.
AU - Scott, Jamil B.
AU - Bennett, Gary G.
AU - Ng, Kimmie
AU - Chan, Andrew T.
AU - Hollis, Bruce W.
AU - Emmons, Karen M.
AU - Fuchs, Charles S.
AU - Drake, Bettina F.
N1 - Publisher Copyright:
© 2014 AACR.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Results: With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA,-0.0004 ng/mL (P = 0.94) and total PSA,-0.004 ng/mL (P = 0.92) for each additional 1, 000 U/d of vitamin D3. Conclusion: Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA.Background: Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men.Methods: During three winters from 2007 to 2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a four-arm, double-blind trial for 3 months of placebo, 1, 000, 2, 000, or 4, 000Uof vitamin D3. At baseline and 3 months, free and total PSA was measured.Impact: These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.
AB - Results: With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA,-0.0004 ng/mL (P = 0.94) and total PSA,-0.004 ng/mL (P = 0.92) for each additional 1, 000 U/d of vitamin D3. Conclusion: Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA.Background: Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men.Methods: During three winters from 2007 to 2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a four-arm, double-blind trial for 3 months of placebo, 1, 000, 2, 000, or 4, 000Uof vitamin D3. At baseline and 3 months, free and total PSA was measured.Impact: These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.
UR - http://www.scopus.com/inward/record.url?scp=84907167034&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-14-0522
DO - 10.1158/1055-9965.EPI-14-0522
M3 - Article
C2 - 24974387
AN - SCOPUS:84907167034
SN - 1055-9965
VL - 23
SP - 1944
EP - 1947
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -