Nucleotide inhibition of adenyl cyclase activity in fat cell membranes

Philip E. Cryer, Leonard Jarett, David M. Kipnis

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A reproducible assay for adenyl cyclase activity in an isolated fat cell membrane preparation is described. Enzyme activity was stimulated by epinephrine and sodium fluoride, but not affected by insulin. GTP, GDP, GMP, CTP and UTP inhibited the adenyl cyclase activity of the fat cell membrane, but guanosine and cyclic GMP had no effect. In contrast to the inhibitory effect on the fat cell membrane enzyme, GTP did not affect either adrenal or kidney adenyl cyclase activity.

Original languageEnglish
Pages (from-to)586-590
Number of pages5
JournalBBA - General Subjects
Issue number3
StatePublished - May 6 1969


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