TY - JOUR
T1 - Nucleic acid triggered catalytic drug and probe release
T2 - A new concept for the design of chemotherapeutic and diagnostic agents
AU - Ma, Zhaochun
AU - Taylor, John Stephen
N1 - Funding Information:
This work was supported in part by NIH grant CA40463 and a Wheeler Fellowship for Z. Ma. The assistance of the Washington University High Resolution NMR Facility, funded in part through NIH Biomedical Research Support Shared Instrument Grants RR-02004, RR-05018, and RR-07155 is gratefully acknowledged, as is the Washington University Mass Spectrometry Resource, an NIH Research Resource (Grant No. P41RR0954).
PY - 2001
Y1 - 2001
N2 - Recently, we described a new concept for the design of highly selective antiviral and anticancer chemotherapeutic agents that makes use of a disease-specific nucleic acid sequence to template the association of a prodrug with a catalyst which catalyzes the release of the drug. Herein, we repor on the effec of mismatches, sterics, and electronics on the rate and specificity of drug and probe release in both two and three component model systems, and on the stability of the prodrug linker in human serum.
AB - Recently, we described a new concept for the design of highly selective antiviral and anticancer chemotherapeutic agents that makes use of a disease-specific nucleic acid sequence to template the association of a prodrug with a catalyst which catalyzes the release of the drug. Herein, we repor on the effec of mismatches, sterics, and electronics on the rate and specificity of drug and probe release in both two and three component model systems, and on the stability of the prodrug linker in human serum.
UR - https://www.scopus.com/pages/publications/0034824703
U2 - 10.1016/S0968-0896(01)00245-0
DO - 10.1016/S0968-0896(01)00245-0
M3 - Article
C2 - 11553492
AN - SCOPUS:0034824703
SN - 0968-0896
VL - 9
SP - 2501
EP - 2510
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 9
ER -