Nuclear survivin as a biomarker for non-small-cell lung cancer

B. Lu; A. Gonzalez; P. P. Massion; Y. Shyr; B. Shaktour; D. F. Carbone; D. E. Hallahan

doi:10.1038/sj.bjc.6602027

Nuclear survivin as a biomarker for non-small-cell lung cancer

B. Lu, A. Gonzalez, P. P. Massion, Y. Shyr, B. Shaktour, D. F. Carbone, D. E. Hallahan

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P = 0.02). Therefore, survivin may be a biomarker for NSCLC.

Original language	English
Pages (from-to)	537-540
Number of pages	4
Journal	British Journal of Cancer
Volume	91
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjc.6602027
State	Published - Aug 2 2004

Keywords

Apoptosis
Lung cancer nucleus
Mitosis
Survivin
Tissue array

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abstract = "Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P = 0.02). Therefore, survivin may be a biomarker for NSCLC.",

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AU - Carbone, D. F.

AU - Hallahan, D. E.

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N2 - Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P = 0.02). Therefore, survivin may be a biomarker for NSCLC.

AB - Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P = 0.02). Therefore, survivin may be a biomarker for NSCLC.

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KW - Lung cancer nucleus

KW - Mitosis

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KW - Tissue array

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Nuclear survivin as a biomarker for non-small-cell lung cancer

Abstract

Keywords

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