Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine

Gyu Seong Heo, Johanna Diekmann, James T. Thackeray, Yongjian Liu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Inflammation is a key mechanistic contributor to the progression of cardiovascular disease, from atherosclerosis through ischemic injury and overt heart failure. Recent evidence has identified specific roles of immune cell subpopulations in cardiac pathogenesis that diverges between individual patients. Nuclear imaging approaches facilitate noninvasive and serial quantification of inflammation severity, offering the opportunity to predict eventual outcome, stratify patient risk, and guide novel targeted molecular therapies against specific leukocyte subpopulations. Here, we will discuss the established and emerging nuclear imaging methods to label and track exogenous and endogenous immune cells, with a particular focus on clinical situations in which targeted molecular inflammation imaging would be advantageous. The expanding options for imaging inflammation provide the foundation to bridge between molecular imaging and individual therapy.

Original languageEnglish
Pages (from-to)E014067
JournalCirculation: Cardiovascular Imaging
Issue number1
StatePublished - Jan 1 2023


  • heart failure
  • inflammation
  • magnetic resonance imaging
  • myocardial infarction
  • positron emission tomography


Dive into the research topics of 'Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine'. Together they form a unique fingerprint.

Cite this