Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies

Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Arpita Vyas

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.

Original languageEnglish
Pages (from-to)3174-3183
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number11
StatePublished - Mar 21 2015


  • Gastrointestinal cancer
  • Inflammation
  • Nuclear factor kappa B


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