TY - JOUR
T1 - Nuclear envelope
T2 - Positioning nuclei and organizing synapses
AU - Razafsky, David
AU - Hodzic, Didier
N1 - Funding Information:
The authors are supported by the National Eye Institute (# R01EY022632 to D.H.), a National Eye Institute Center Core Grant (# P30EY002687 ), an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences, the Small Grant Program from The McDonnell Center for Cellular and Molecular Neurobiology and the HOPE Center for Neurological Disorders at Washington University School of Medicine. The authors declare no competing financial interests.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.
AB - The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.
UR - http://www.scopus.com/inward/record.url?scp=84931266956&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2015.06.001
DO - 10.1016/j.ceb.2015.06.001
M3 - Review article
C2 - 26079712
AN - SCOPUS:84931266956
SN - 0955-0674
VL - 34
SP - 84
EP - 93
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -