Nuclear envelope: Positioning nuclei and organizing synapses

David Razafsky, Didier Hodzic

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.

Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume34
DOIs
StatePublished - Jun 1 2015

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