NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

Zhou Feng Chen, Alice J. Paquette, David J. Anderson

Research output: Contribution to journalArticlepeer-review

390 Scopus citations

Abstract

The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription from neuronal promoters in non-neuronal cell lines, but its function during normal development is unknown. In mice, a targeted mutation of Rest, the gene encoding NRSF, caused derepression of neuron- specific tubulin in a subset of non-neural tissues and embryonic lethality. Mosaic inhibition of NRSF in chicken embryos, using a dominant-negative form of NRSF, also caused derepression of neuronal tubulin, as well as of several other neuronal target genes, in both non-neural tissues and central nervous system neuronal progenitors. These results indicate that NRSF is required to repress neuronal gene expression in vivo, in both extra-neural and undifferentiated neural tissue.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalNature Genetics
Volume20
Issue number2
DOIs
StatePublished - 1998

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