Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot.

L. B. Piotrovskii; P. V. Lishko; A. P. Maksimiuk; I. I. Aleksandrova; O. A. Kryshtal'

Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot.

Translated title of the contribution: A new class of N-methyl-D-aspartic acid receptor agonists and antagonists--derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids

L. B. Piotrovskii, P. V. Lishko, A. P. Maksimiuk, I. I. Aleksandrova, O. A. Kryshtal'

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

New agonists and antagonists of the N-methyl-D-aspartic acid (NMDA) receptors were found among the derivatives of 1- or 2-alkyl-substituted imidazole-4,5- and pyrazole-3,4-dicarboxylic acids. Lipophilic surrounding of the nitrogen atom in these compounds was found to determine their ability to be either agonists or antagonists, while the distance between the terminal acidic functions was the same. An increase in the lipophilicity can also cause loss of selective action upon the NMDA receptors and occurrence of non- NMDA antagonistic activity.

Translated title of the contribution	A new class of N-methyl-D-aspartic acid receptor agonists and antagonists--derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids
Original language	Russian
Pages (from-to)	523-530
Number of pages	8
Journal	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume	85
Issue number	4
State	Published - Apr 1999

Cite this

@article{9eef36a541514004bd9c33b4b7ae6660,

title = "Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot.",

abstract = "New agonists and antagonists of the N-methyl-D-aspartic acid (NMDA) receptors were found among the derivatives of 1- or 2-alkyl-substituted imidazole-4,5- and pyrazole-3,4-dicarboxylic acids. Lipophilic surrounding of the nitrogen atom in these compounds was found to determine their ability to be either agonists or antagonists, while the distance between the terminal acidic functions was the same. An increase in the lipophilicity can also cause loss of selective action upon the NMDA receptors and occurrence of non- NMDA antagonistic activity.",

author = "Piotrovskii, {L. B.} and Lishko, {P. V.} and Maksimiuk, {A. P.} and Aleksandrova, {I. I.} and Kryshtal', {O. A.}",

year = "1999",

month = apr,

language = "Russian",

volume = "85",

pages = "523--530",

journal = "Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk",

issn = "0869-8139",

number = "4",

}

Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot. / Piotrovskii, L. B.; Lishko, P. V.; Maksimiuk, A. P. et al.
In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 85, No. 4, 04.1999, p. 523-530.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot.

AU - Piotrovskii, L. B.

AU - Lishko, P. V.

AU - Maksimiuk, A. P.

AU - Aleksandrova, I. I.

AU - Kryshtal', O. A.

PY - 1999/4

Y1 - 1999/4

N2 - New agonists and antagonists of the N-methyl-D-aspartic acid (NMDA) receptors were found among the derivatives of 1- or 2-alkyl-substituted imidazole-4,5- and pyrazole-3,4-dicarboxylic acids. Lipophilic surrounding of the nitrogen atom in these compounds was found to determine their ability to be either agonists or antagonists, while the distance between the terminal acidic functions was the same. An increase in the lipophilicity can also cause loss of selective action upon the NMDA receptors and occurrence of non- NMDA antagonistic activity.

AB - New agonists and antagonists of the N-methyl-D-aspartic acid (NMDA) receptors were found among the derivatives of 1- or 2-alkyl-substituted imidazole-4,5- and pyrazole-3,4-dicarboxylic acids. Lipophilic surrounding of the nitrogen atom in these compounds was found to determine their ability to be either agonists or antagonists, while the distance between the terminal acidic functions was the same. An increase in the lipophilicity can also cause loss of selective action upon the NMDA receptors and occurrence of non- NMDA antagonistic activity.

UR - http://www.scopus.com/inward/record.url?scp=0033112367&partnerID=8YFLogxK

M3 - Article

C2 - 10513386

AN - SCOPUS:0033112367

SN - 0869-8139

VL - 85

SP - 523

EP - 530

JO - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk

JF - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk

IS - 4

ER -

Novyi klass agonistov i antagonistov retseptorov N-metil-D-asparaginovoi kisloty--proizvodnye imidazol-4,5- i pirazol-3,4-dikarbonovykh kislot.

Abstract

Other files and links

Fingerprint

Cite this