TY - JOUR
T1 - Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles
AU - Le Bourdonnec, Bertrand
AU - Barker, William M.
AU - Belanger, Serge
AU - Wiant, Daniel D.
AU - Conway-James, Nathalie C.
AU - Cassel, Joel A.
AU - O'Neill, Timothy J.
AU - Little, Patrick J.
AU - DeHaven, Robert N.
AU - DeHaven-Hudkins, Diane L.
AU - Dolle, Roland E.
PY - 2008/3/15
Y1 - 2008/3/15
N2 - A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, μ opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective μ opioid receptor antagonist, which interacts selectively with μ peripheral receptors.
AB - A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, μ opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective μ opioid receptor antagonist, which interacts selectively with μ peripheral receptors.
KW - Opioid
KW - Solid phase synthesis
KW - μ receptors
UR - http://www.scopus.com/inward/record.url?scp=40749139396&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.01.106
DO - 10.1016/j.bmcl.2008.01.106
M3 - Article
C2 - 18313920
AN - SCOPUS:40749139396
SN - 0960-894X
VL - 18
SP - 2006
EP - 2012
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 6
ER -