Novel selective allosteric activator of the M₁ muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats

Keyphrases

• Allosteric Inhibitor 100%
• Muscarinic Acetylcholine Receptor 100%
• Antipsychotic Activity 100%
• M1 muscarinic Acetylcholine Receptor 100%
• Amyloid Processing 100%
• Adverse Effects 66%
• Alzheimer's Disease 66%
• Schizophrenia Symptoms 66%
• Alzheime's Disease 66%
• Binding Site 33%
• Amyloid Precursor Protein 33%
• Clinical Data 33%
• Allosteric Site 33%
• Patch-clamp Recording 33%
• Mutagenesis 33%
• Muscarinic Agonists 33%
• Highly Selective 33%
• Acetylcholine 33%
• Subtype Selectivity 33%
• Agonist Activity 33%
• Inhibitory Postsynaptic Current 33%
• Excitatory Synaptic Transmission 33%
• Clinical Development 33%
• Pyramidal Neurons 33%
• Molecular Pharmacology 33%
• Psychotic Symptoms 33%
• Catalepsy 33%
• Selective Activation 33%
• Selective Agonist 33%
• Subtype Specificity 33%
• Orthosteric 33%
• Pharmacology Studies 33%
• M4 muscarinic Acetylcholine Receptor 33%
• Specificity Effects 33%
• Transmission Response 33%
• M1 Receptor 33%
• NMDA Receptor Current 33%
• Selective Activator 33%
• Non-amyloidogenic Pathway 33%
• Predictive Model 33%
• 1H-benzo[d]imidazole 33%

Neuroscience

• Agonist 100%
• Amyloid Protein 100%
• Muscarinic Acetylcholine Receptor M1 100%
• Antipsychotic 100%
• Alzheimer's Disease 66%
• Schizophrenia 66%
• Adverse Effect 66%
• In Vitro 33%
• Patch Clamp Technique 33%
• Amyloid Precursor Protein 33%
• Binding Site 33%
• Pyramidal Cell 33%
• Acetylcholine 33%
• Synaptic Transmission 33%
• NMDA Receptor 33%
• Molecular Pharmacology 33%
• Allosteric Site 33%
• Muscarinic Acetylcholine Receptor M4 33%
• Muscarinic Agonist 33%
• Catalepsy 33%
• Receptor 33%
• Mutagenesis 33%