TY - JOUR
T1 - Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
AU - Sala-Rabanal, Monica
AU - Yurtsever, Zeynep
AU - Berry, Kayla N.
AU - Brett, Tom J.
N1 - Publisher Copyright:
© 2015 Monica Sala-Rabanal et al.
PY - 2015
Y1 - 2015
N2 - Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
AB - Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
UR - http://www.scopus.com/inward/record.url?scp=84947276437&partnerID=8YFLogxK
U2 - 10.1155/2015/497387
DO - 10.1155/2015/497387
M3 - Review article
C2 - 26612971
AN - SCOPUS:84947276437
SN - 0962-9351
VL - 2015
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 497387
ER -