TY - JOUR
T1 - Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists
AU - Chu, Guo Hua
AU - Saeui, Christopher T.
AU - Worm, Karin
AU - Weaver, Damian G.
AU - Goodman, Allan J.
AU - Broadrup, Robert L.
AU - Cassel, Joel A.
AU - DeHaven, Robert N.
AU - LaBuda, Christopher J.
AU - Koblish, Michael
AU - Brogdon, Bernice
AU - Smith, Steve
AU - Bourdonnec, Bertrand Le
AU - Dolle, Roland E.
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.
AB - Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain.
KW - Cannabinoid receptors
KW - Pain
KW - Pyridine derivatives
KW - Selective CB agonists
UR - http://www.scopus.com/inward/record.url?scp=70349220863&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2009.08.063
DO - 10.1016/j.bmcl.2009.08.063
M3 - Article
C2 - 19736007
AN - SCOPUS:70349220863
SN - 0960-894X
VL - 19
SP - 5931
EP - 5935
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 20
ER -