Novel paramagnetic contrast agents for molecular imaging and targeted drug delivery

Gregory M. Lanza, Patrick Winter, Shelton Caruthers, Anne Schmeider, Kathy Crowder, Anne Morawski, Huiying Zhang, Michael J. Scott, Samuel A. Wickline

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Molecular biology and genomic sciences are revealing the early biological signatures for many diseases. In response, the Molecular Imaging community is rapidly developing contrast agents to visualize the nascent pathological changes and to concomitantly deliver treatment directly to the site of disease. The evaluation, development and use of these new agents require a complementary understanding of contrast chemistry and imaging techniques. The fundamental issues surrounding magnetic contrast agent development, rational drug delivery, MR molecular imaging, and their interdependence are elucidated.

Original languageEnglish
Pages (from-to)495-507
Number of pages13
JournalCurrent Pharmaceutical Biotechnology
Volume5
Issue number6
DOIs
StatePublished - Dec 2004

Keywords

  • Drug delivery
  • Magnetic resonance imaging
  • Molecular imaging
  • Nanoparticle
  • Nanotechnology
  • Restenosis
  • Vascular smooth muscle cells

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