TY - JOUR
T1 - Novel Myocardial PET/CT Receptor Imaging and Potential Therapeutic Targets
AU - Valenta, Ines
AU - Pacher, Pal
AU - Dilsizian, Vasken
AU - Schindler, Thomas H.
N1 - Funding Information:
Funding This work was supported by a Departmental Fund from Washington University in St. Louis (No. 12–3271-93128 to Dr. Schindler), and the Intramural Research Program of National Institute on Alcohol Abuse and Alcoholism/National Institutes of Health (to Dr. Pacher).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Purpose of the Review: Activation of myocardial cannabinoid type 1 receptors (CB1-R) and/or angiotensin II type 1 receptors (AT1-R) likely plays an important mechanistic role in determining the left-ventricular remodeling process in systolic heart failure. We provide an overview on novel radiotracer probes and positron emission tomography (PET)/computed tomography (CT) imaging to noninvasively probe the expression of myocardial CB1-R and/or AT1-R. Recent Findings: Recent translational investigations have demonstrated the feasibility of 11C-OMAR or 11C-KR31173 and PET/CT to image and quantify myocardial CB1-R and/or AT1-R expression, respectively. There is an increasing understanding of the mechanisms of activated myocardial CB1-R and/or AT1-R to influence the left-ventricular remodeling process in systolic heart failure in different disease entities. Summary: The review summarizes contributions of PET to image myocardial CB1-R and AT1-R expression that may have the potential to serve as a target to tailor preventive medical care in the individual patient.
AB - Purpose of the Review: Activation of myocardial cannabinoid type 1 receptors (CB1-R) and/or angiotensin II type 1 receptors (AT1-R) likely plays an important mechanistic role in determining the left-ventricular remodeling process in systolic heart failure. We provide an overview on novel radiotracer probes and positron emission tomography (PET)/computed tomography (CT) imaging to noninvasively probe the expression of myocardial CB1-R and/or AT1-R. Recent Findings: Recent translational investigations have demonstrated the feasibility of 11C-OMAR or 11C-KR31173 and PET/CT to image and quantify myocardial CB1-R and/or AT1-R expression, respectively. There is an increasing understanding of the mechanisms of activated myocardial CB1-R and/or AT1-R to influence the left-ventricular remodeling process in systolic heart failure in different disease entities. Summary: The review summarizes contributions of PET to image myocardial CB1-R and AT1-R expression that may have the potential to serve as a target to tailor preventive medical care in the individual patient.
KW - Angiotensin II type 1 receptors
KW - Angiotensin-converting enzyme
KW - Cannabinoid type 1 receptor
KW - Heart failure
KW - Left-ventricular remodeling
KW - Obesity
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85065973280&partnerID=8YFLogxK
U2 - 10.1007/s11886-019-1148-2
DO - 10.1007/s11886-019-1148-2
M3 - Review article
C2 - 31104205
AN - SCOPUS:85065973280
SN - 1523-3782
VL - 21
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 7
M1 - 55
ER -