Novel MR imaging and theranostics using Nano-DDS

Ichio Aoki, Jun Ichiro Jo, Horacio Cabra, Rumiana Bakalova, Kevin M. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

Nano-DDSs have provided many improvements, such as sensitivity, multimodality, ability to respond to the environment or an external trigger, and theranostics (therapeutics and diagnostics), for preclinical magnetic resonance imaging (MRI). Nanocarriers like polymers, nano-micelle, carbon nano-materials (fullerene and carbon nanotube), and PEGylated liposome, have been investigated and the merits and limitations of each have slowly become clear. This review discusses the progress and unresolved issues for existing nano-DDSs for MRI applications, and summarizes recent work with responsive and theranostic nanocarriers.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalDrug Delivery System
Volume30
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Activatable contrast agents
  • MRI
  • Nanoparticles
  • Responsive contrast agents
  • Theranostics

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