Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of β-galactosidase activity

Xiaojin Li, Zhongwei Zhang, Zijun Yu, Jennifer Magnusson, Jian Xin Yu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.

Original languageEnglish
Pages (from-to)1360-1367
Number of pages8
JournalMolecular Pharmaceutics
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

Keywords

  • T and T relaxation times
  • responsive Fe-based H-MRI agent
  • synthesis
  • β-galactosidase detection

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