Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of β-galactosidase activity

Xiaojin Li; Zhongwei Zhang; Zijun Yu; Jennifer Magnusson; Jian Xin Yu

doi:10.1021/mp300627t

Novel molecular platform integrated iron chelation therapy for ¹H-MRI detection of β-galactosidase activity

Xiaojin Li, Zhongwei Zhang, Zijun Yu, Jennifer Magnusson, Jian Xin Yu

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Targeting the increased Fe³⁺ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for ¹H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by ¹H-MRI T₁ and T ₂ relaxation mapping.

Original language	English
Pages (from-to)	1360-1367
Number of pages	8
Journal	Molecular Pharmaceutics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/mp300627t
State	Published - Apr 1 2013

Keywords

T and T relaxation times
responsive Fe-based H-MRI agent
synthesis
β-galactosidase detection

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10.1021/mp300627t

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abstract = "Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.",

keywords = "T and T relaxation times, responsive Fe-based H-MRI agent, synthesis, β-galactosidase detection",

author = "Xiaojin Li and Zhongwei Zhang and Zijun Yu and Jennifer Magnusson and Yu, {Jian Xin}",

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AU - Li, Xiaojin

AU - Zhang, Zhongwei

AU - Yu, Zijun

AU - Magnusson, Jennifer

AU - Yu, Jian Xin

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.

AB - Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.

KW - T and T relaxation times

KW - responsive Fe-based H-MRI agent

KW - synthesis

KW - β-galactosidase detection

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JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

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ER -

Novel molecular platform integrated iron chelation therapy for ¹H-MRI detection of β-galactosidase activity

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Keywords

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