Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of β-galactosidase activity

Xiaojin Li; Zhongwei Zhang; Zijun Yu; Jennifer Magnusson; Jian Xin Yu

doi:10.1021/mp300627t

Novel molecular platform integrated iron chelation therapy for ¹H-MRI detection of β-galactosidase activity

Xiaojin Li, Zhongwei Zhang, Zijun Yu, Jennifer Magnusson, Jian Xin Yu

Section of Pediatric Radiology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Targeting the increased Fe³⁺ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for ¹H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by ¹H-MRI T₁ and T ₂ relaxation mapping.

Original language	English
Pages (from-to)	1360-1367
Number of pages	8
Journal	Molecular Pharmaceutics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/mp300627t
State	Published - Apr 1 2013

Keywords

T and T relaxation times
responsive Fe-based H-MRI agent
synthesis
β-galactosidase detection

Access to Document

10.1021/mp300627t

Cite this

@article{b868a47c18204c3ca50445d9aaf4c1fe,

title = "Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of β-galactosidase activity",

abstract = "Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.",

keywords = "T and T relaxation times, responsive Fe-based H-MRI agent, synthesis, β-galactosidase detection",

author = "Xiaojin Li and Zhongwei Zhang and Zijun Yu and Jennifer Magnusson and Yu, {Jian Xin}",

year = "2013",

month = apr,

day = "1",

doi = "10.1021/mp300627t",

language = "English",

volume = "10",

pages = "1360--1367",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

number = "4",

}

TY - JOUR

T1 - Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of β-galactosidase activity

AU - Li, Xiaojin

AU - Zhang, Zhongwei

AU - Yu, Zijun

AU - Magnusson, Jennifer

AU - Yu, Jian Xin

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.

AB - Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.

KW - T and T relaxation times

KW - responsive Fe-based H-MRI agent

KW - synthesis

KW - β-galactosidase detection

UR - http://www.scopus.com/inward/record.url?scp=84875780014&partnerID=8YFLogxK

U2 - 10.1021/mp300627t

DO - 10.1021/mp300627t

M3 - Article

C2 - 23391334

AN - SCOPUS:84875780014

SN - 1543-8384

VL - 10

SP - 1360

EP - 1367

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 4

ER -

Novel molecular platform integrated iron chelation therapy for ¹H-MRI detection of β-galactosidase activity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this