Abstract
Targeting the increased Fe3+ content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-magnetic resonance imaging (MRI) detection of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized, and characterized a series of β-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing β-gal activity in solution by 1H-MRI T1 and T 2 relaxation mapping.
Original language | English |
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Pages (from-to) | 1360-1367 |
Number of pages | 8 |
Journal | Molecular Pharmaceutics |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2013 |
Keywords
- T and T relaxation times
- responsive Fe-based H-MRI agent
- synthesis
- β-galactosidase detection