Novel malonamide derivatives as potent κ opioid receptor agonists

  • Guo Hua Chu
  • , Minghua Gu
  • , Joel A. Cassel
  • , Serge Belanger
  • , Thomas M. Graczyk
  • , Robert N. DeHaven
  • , Nathalie Conway-James
  • , Michael Koblish
  • , Patrick J. Little
  • , Diane L. DeHaven-Hudkins
  • , Roland E. Dolle

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective κ opioid receptor agonists.

Original languageEnglish
Pages (from-to)1951-1955
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number7
DOIs
StatePublished - Apr 1 2007

Keywords

  • Analgesic
  • Opioid
  • κ Agonist

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