Novel malonamide derivatives as potent κ opioid receptor agonists

Guo Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Michael Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective κ opioid receptor agonists.

Original languageEnglish
Pages (from-to)1951-1955
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
StatePublished - Apr 1 2007


  • Analgesic
  • Opioid
  • κ Agonist


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