Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

N. D. Carter; W. R. Chegwidden; D. Hewett-Emmett; S. Jeffery; A. Shiels; R. E. Tashian

doi:10.1016/0014-5793(84)80168-4

Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

N. D. Carter, W. R. Chegwidden, D. Hewett-Emmett, S. Jeffery, A. Shiels, R. E. Tashian

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.

Original language	English
Pages (from-to)	197-200
Number of pages	4
Journal	FEBS Letters
Volume	165
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(84)80168-4
State	Published - Jan 9 1984

Keywords

Carbamoyl phosphate
Carbamoyl phosphate synthetase
Carbonic anhydrase isozyme
Enzyme inhibition
Urea cycle

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10.1016/0014-5793(84)80168-4

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title = "Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate",

abstract = "Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.",

keywords = "Carbamoyl phosphate, Carbamoyl phosphate synthetase, Carbonic anhydrase isozyme, Enzyme inhibition, Urea cycle",

author = "Carter, {N. D.} and Chegwidden, {W. R.} and D. Hewett-Emmett and S. Jeffery and A. Shiels and Tashian, {R. E.}",

note = "Funding Information: This work was supportedi n part by grantsf rom the Muscular Dystrophy Group, (to N.D.C.) and the National Instituteso f Health (GM 24681t o R.E.T.)",

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doi = "10.1016/0014-5793(84)80168-4",

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TY - JOUR

T1 - Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

AU - Carter, N. D.

AU - Chegwidden, W. R.

AU - Hewett-Emmett, D.

AU - Jeffery, S.

AU - Shiels, A.

AU - Tashian, R. E.

N1 - Funding Information: This work was supportedi n part by grantsf rom the Muscular Dystrophy Group, (to N.D.C.) and the National Instituteso f Health (GM 24681t o R.E.T.)

PY - 1984/1/9

Y1 - 1984/1/9

N2 - Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.

AB - Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.

KW - Carbamoyl phosphate

KW - Carbamoyl phosphate synthetase

KW - Carbonic anhydrase isozyme

KW - Enzyme inhibition

KW - Urea cycle

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U2 - 10.1016/0014-5793(84)80168-4

DO - 10.1016/0014-5793(84)80168-4

M3 - Article

C2 - 6420187

AN - SCOPUS:0021758372

SN - 0014-5793

VL - 165

SP - 197

EP - 200

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

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