Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

N. D. Carter, W. R. Chegwidden, D. Hewett-Emmett, S. Jeffery, A. Shiels, R. E. Tashian

Research output: Contribution to journalArticle

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Abstract

Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalFEBS Letters
Volume165
Issue number2
DOIs
StatePublished - Jan 9 1984
Externally publishedYes

Keywords

  • Carbamoyl phosphate
  • Carbamoyl phosphate synthetase
  • Carbonic anhydrase isozyme
  • Enzyme inhibition
  • Urea cycle

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    Carter, N. D., Chegwidden, W. R., Hewett-Emmett, D., Jeffery, S., Shiels, A., & Tashian, R. E. (1984). Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate. FEBS Letters, 165(2), 197-200. https://doi.org/10.1016/0014-5793(84)80168-4