Abstract

In recent years, diverse and unexpected neurobiological functions have been uncovered for the major cell cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC). Functions of the APC in the nervous system range from orchestrating neuronal morphogenesis and synapse development to the regulation of neuronal differentiation, survival, and metabolism. The APC acts together with the coactivating proteins Cdh1 and Cdc20 in neural cells to target specific substrates for ubiquitination and consequent degradation by the proteasome. As we continue to unravel APC functions and mechanisms in neurobiology, these studies should advance our understanding of the molecular mechanisms of neuronal connectivity, with important implications for the study of brain development and disease.

Original languageEnglish
Pages (from-to)586-594
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number6
DOIs
StatePublished - Aug 2011

Keywords

  • Axons
  • Cdc20-APC
  • Cdh1-APC
  • Dendrites
  • Synapses

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