Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins

Elaine L. Shelton; Gautam K. Singh; Colin G. Nichols

doi:10.1053/j.semperi.2018.05.004

Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins

Elaine L. Shelton, Gautam K. Singh, Colin G. Nichols

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE₁) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.

Original language	English
Pages (from-to)	221-227
Number of pages	7
Journal	Seminars in Perinatology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1053/j.semperi.2018.05.004
State	Published - Jun 2018

Keywords

KATP channel
PDA
ductus arteriosus
novel drug targets

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title = "Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins",

abstract = "Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE1) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.",

keywords = "KATP channel, PDA, ductus arteriosus, novel drug targets",

author = "Shelton, {Elaine L.} and Singh, {Gautam K.} and Nichols, {Colin G.}",

note = "Funding Information: This work was supported by R21HL132805 and AHA15SDG25280015 awarded to ELS and R35HL140024 awarded to CGN. Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = jun,

doi = "10.1053/j.semperi.2018.05.004",

language = "English",

volume = "42",

pages = "221--227",

journal = "Seminars in Perinatology",

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T2 - Looking beyond prostaglandins

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AU - Singh, Gautam K.

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N2 - Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE1) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.

AB - Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE1) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.

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DO - 10.1053/j.semperi.2018.05.004

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Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins

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Keywords

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