TY - JOUR
T1 - Novel drug targets for ductus arteriosus manipulation
T2 - Looking beyond prostaglandins
AU - Shelton, Elaine L.
AU - Singh, Gautam K.
AU - Nichols, Colin G.
PY - 2018/6
Y1 - 2018/6
N2 - Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE1) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.
AB - Forty years ago, non-steroidal anti-inflammatory drugs were first reported to decrease systemic prostaglandin levels and promote ductus arteriosus (DA) closure. And yet, prolonged patency of the DA (PDA) remains a significant clinical problem, complicated by imperfect therapies and wide variations in treatment strategy. There are few pharmacology-based tools available for treating PDA (indomethacin, ibuprofen, and acetaminophen), or for maintaining DA patency (PGE1) as is needed to facilitate corrective surgery for ductus-dependent congenital heart defects. Unfortunately, all of these treatments are inefficient and are associated with concerning adverse effects. This review highlights novel potential DA drug targets that may expand our therapeutic repertoire beyond the prostaglandin pathway.
KW - KATP channel
KW - PDA
KW - ductus arteriosus
KW - novel drug targets
UR - http://www.scopus.com/inward/record.url?scp=85048587656&partnerID=8YFLogxK
U2 - 10.1053/j.semperi.2018.05.004
DO - 10.1053/j.semperi.2018.05.004
M3 - Review article
C2 - 29880312
AN - SCOPUS:85048587656
VL - 42
SP - 221
EP - 227
JO - Seminars in Perinatology
JF - Seminars in Perinatology
SN - 0146-0005
IS - 4
ER -