@inproceedings{1d1d93073330471c89c5bcb54ac643e2,
title = "Novel design of multimodal MRI/NIR optical contrast agent",
abstract = "We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro. The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist{\textregistered} and Multihance{\textregistered} and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.",
author = "Kevin Guo and Franck Lin and Walter Akers and Jie Zheng and Bao Teng and Olga Vasalatiy and Griffiths, {Gary L.} and Amir Gandjbakhche and Berezin, {Mikhail Y.} and Samuel Achilefu",
note = "Copyright: Copyright 2011 Elsevier B.V., All rights reserved.; Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III ; Conference date: 24-01-2011 Through 26-01-2011",
year = "2011",
doi = "10.1117/12.881395",
language = "English",
isbn = "9780819484475",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III",
}