Novel design of multimodal MRI/NIR optical contrast agent

Kevin Guo, Franck Lin, Walter Akers, Jie Zheng, Bao Teng, Olga Vasalatiy, Gary L. Griffiths, Amir Gandjbakhche, Mikhail Y. Berezin, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro. The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist® and Multihance® and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.

Original languageEnglish
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
DOIs
StatePublished - 2011
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7910
ISSN (Print)1605-7422

Conference

ConferenceReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/24/1101/26/11

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