Novel arterial pathology in mice and humans hemizygous for elastin

Dean Y. Li, Gilles Faury, Douglas G. Taylor, Elaine C. Davis, Walter A. Boyle, Robert P. Mecham, Peter Stenzel, Beth Boak, Mark T. Keating

Research output: Contribution to journalArticle

248 Scopus citations

Abstract

Obstructive vascular disease is an important health problem in the industrialized world. Through a series of molecular genetic studies, we demonstrated that loss-of-function mutations in one elastin allele cause an inherited obstructive arterial disease, supravalvular aortic stenosis (SVAS). To define the mechanism of elastin's effect, we generated mice hemizygous for the elastin gene (ELN +/-). Although ELN mRNA and protein were reduced by 50% in ELN +/- mice, arterial compliance at physiologic pressures was nearly normal. This discrepancy was explained by a paradoxical increase of 35% in the number of elastic lamellae and smooth muscle in ELN +/- arteries. Examination of humans with ELN hemizygosity revealed a 2.5-fold increase in elastic lamellae and smooth muscle. Thus, ELN hemizygosity in mice and humans induces a compensatory increase in the number of rings of elastic lamellae and smooth muscle during arterial development. Humans are exquisitely sensitive to reduced ELN expression, developing profound arterial thickening and markedly increased risk of obstructive vascular disease.

Original languageEnglish
Pages (from-to)1783-1787
Number of pages5
JournalJournal of Clinical Investigation
Volume102
Issue number10
DOIs
StatePublished - Nov 15 1998

Keywords

  • Cardiovascular models
  • Compliance
  • Elastin
  • Mice, transgenic
  • Vascular disease

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    Li, D. Y., Faury, G., Taylor, D. G., Davis, E. C., Boyle, W. A., Mecham, R. P., Stenzel, P., Boak, B., & Keating, M. T. (1998). Novel arterial pathology in mice and humans hemizygous for elastin. Journal of Clinical Investigation, 102(10), 1783-1787. https://doi.org/10.1172/JCI4487