Novel and potent anti-malarial agents

Kristin M. Brinner; Jin Mi Kim; Hiromu Habashita; Ilya Y. Gluzman; Daniel E. Goldberg; Jonathan A. Ellman

doi:10.1016/S0968-0896(02)00207-9

Novel and potent anti-malarial agents

Kristin M. Brinner
, Jin Mi Kim
, Hiromu Habashita
, Ilya Y. Gluzman
, Daniel E. Goldberg
, Jonathan A. Ellman

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC₅₀ values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.

Original language	English
Pages (from-to)	3649-3661
Number of pages	13
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	11
DOIs	https://doi.org/10.1016/S0968-0896(02)00207-9
State	Published - Nov 2002

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title = "Novel and potent anti-malarial agents",

abstract = "Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.",

author = "Brinner, \{Kristin M.\} and \{Mi Kim\}, Jin and Hiromu Habashita and Gluzman, \{Ilya Y.\} and Goldberg, \{Daniel E.\} and Ellman, \{Jonathan A.\}",

note = "Funding Information: We gratefully acknowledge the support of the Medicines for Malaria Venture and the Burroughs Wellcome Foundation. The Center for New Directions in Organic Synthesis is supported by Bristol-Myers Squibb as Sponsoring Member. ",

year = "2002",

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doi = "10.1016/S0968-0896(02)00207-9",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - Novel and potent anti-malarial agents

AU - Brinner, Kristin M.

AU - Mi Kim, Jin

AU - Habashita, Hiromu

AU - Gluzman, Ilya Y.

AU - Goldberg, Daniel E.

AU - Ellman, Jonathan A.

N1 - Funding Information: We gratefully acknowledge the support of the Medicines for Malaria Venture and the Burroughs Wellcome Foundation. The Center for New Directions in Organic Synthesis is supported by Bristol-Myers Squibb as Sponsoring Member.

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Y1 - 2002/11

N2 - Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.

AB - Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.

UR - https://www.scopus.com/pages/publications/0036836673

U2 - 10.1016/S0968-0896(02)00207-9

DO - 10.1016/S0968-0896(02)00207-9

M3 - Article

C2 - 12213481

AN - SCOPUS:0036836673

SN - 0968-0896

VL - 10

SP - 3649

EP - 3661

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 11

ER -

Novel and potent anti-malarial agents

Abstract

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