Novel and potent anti-malarial agents

Kristin M. Brinner, Jin Mi Kim, Hiromu Habashita, Ilya Y. Gluzman, Daniel E. Goldberg, Jonathan A. Ellman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.

Original languageEnglish
Pages (from-to)3649-3661
Number of pages13
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number11
DOIs
StatePublished - Nov 2002

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