TY - JOUR
T1 - Novel Analogues of Enkephalin
T2 - Identification of Functional Groups Required for Biological Activity
AU - Gorin, Fredric A.
AU - Balasubramanian, T. M.
AU - Cicero, Theodore J.
AU - Schwietzer, John
AU - Marshall, Garland R.
PY - 1980/10/1
Y1 - 1980/10/1
N2 - Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have signficiant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5xs]enkephalin and morphine.
AB - Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have signficiant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5xs]enkephalin and morphine.
UR - http://www.scopus.com/inward/record.url?scp=0019219304&partnerID=8YFLogxK
U2 - 10.1021/jm00184a010
DO - 10.1021/jm00184a010
M3 - Article
C2 - 6252322
AN - SCOPUS:0019219304
SN - 0022-2623
VL - 23
SP - 1113
EP - 1122
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 10
ER -